LncRNA RUSC1-AS1 promotes the proliferation of hepatocellular carcinoma cells through modulating NOTCH signaling

The long non-coding RNA (lncRNA) RUSC1-AS1 has been reported to be dysregulated in the progression of many cancers. Also, had detected highly expressed laryngeal squamous cell carcinoma and breast cancer cells, suggesting that may a biomarker for However, biological role regulatory mechanism hepatocellular (HCC) remain unknown. In this study, we found was upregulated HCC tissues predicted unfavorable prognosis patients. function assays including colony formation, EdU, TUNEL assay revealed facilitated proliferation inhibited apoptosis. Furthermore, luciferase reporter RIP demonstrated could directly bind hsa-miR-7-5p. Besides, hsa-miR-7-5p targeted negatively regulated NOTCH3 expression. Moreover, sponged upregulate trigger NOTCH signaling pathway. rescue depicted apoptosis through modulating signaling. conclusion, lncRNA promoted reduced cells activation via hsa-miR-7-5p/NOTCH3 axis.